Estradiol Transdermal Patch
194 interactions 765 cited references
Also sold as:
Alora®
Climara®
Esclim®
Estraderm®
FemPatch®
Menostar
Menostar®
Minivelle®
Vivelle-Dot®
Vivelle®
About Estradiol Transdermal Patch
Transdermal estradiol (Climara, Minivelle, Vivelle-Dot) is used to treat hot flashes (hot flushes; sudden feelings of mild or intense body heat) in women who are experiencing menopause (change of life; the end of monthly menstrual periods). Transdermal estradiol (Climara, Vivelle-Dot) is also used to treat vaginal dryn… Read the full Estradiol Transdermal Patch drug information page →
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Aug 9, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Contraindicated
Estradiol Transdermal Patch Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Estradiol Transdermal Patch Fezolinetant Increased fezolinetant exposure Details Estradiol Transdermal Patch Tranexamic Acid Cyklokapron An increased risk of thrombotic events DetailsMajor
Estradiol Transdermal Patch Abametapir Increased exposure of CYP3A4 substrate Details Estradiol Transdermal Patch Alfentanil Increased ALfentanil exposure, an increased risk of ALfentanil-related adverse reactions and/or prolonged effects, which may exace... Details Estradiol Transdermal Patch Amifampridine Increased risk of seizures Details Estradiol Transdermal Patch Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Estradiol Transdermal Patch Ampicillin Amcill® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Amprenavir Reduced amprenavir exposure, altered hormonal levels, loss of contraceptive efficacy, and an increased risk of liver enzyme elevat... Details Estradiol Transdermal Patch Apalutamide Erleada Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Transdermal Patch Aprepitant Aponvie Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Estradiol Transdermal Patch Armodafinil Nuvigil Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Transdermal Patch Avacopan Tavneos Increased CYP3A4 substrate exposure Details Estradiol Transdermal Patch Bacampicillin Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Belzutifan Welireg An increased belzutifan exposure, an increased risk of belzutifan-related adverse effects, reduced hormonal contraceptives exposur... Details Estradiol Transdermal Patch Betamethasone Betavet Increased corticosteroid effects Details Estradiol Transdermal Patch Bexarotene Targretin Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Bosentan Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Estradiol Transdermal Patch Bupropion Aplenzin Increased risk of seizures Details Estradiol Transdermal Patch Carbamazepine Carbatrol Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Estradiol Transdermal Patch Carbenicillin Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefaclor Ceclor® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefadroxil Duricef® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefdinir Omnicef® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefditoren Spectracef® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefixime Suprax Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefpodoxime Banan® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefprozil Cefzil® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Ceftazidime Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Ceftibuten Cedax® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cefuroxime Ceftin® Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cenobamate Xcopri Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Estradiol Transdermal Patch Ceritinib Zykadia Increased CYP3A substrate exposure Details Estradiol Transdermal Patch Clarithromycin Biaxin Increased exposure of CYP3A4 substrate and risk for toxicity Details Estradiol Transdermal Patch Clobazam Onfi Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Cloxacillin Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Clozapine Clozaril Increased clozapine exposure and increased risk of adverse effects Details Estradiol Transdermal Patch Colesevelam Welchol Decreased contraceptive effectiveness Details Estradiol Transdermal Patch Conivaptan Vaprisol Increased CYP3A substrate exposure Details Estradiol Transdermal Patch Cosyntropin Increased cortisol exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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