Ethambutol

Name: Ethambutol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 92 cited references

Also sold as: Myambutol Myambutol®

About Ethambutol

Ethambutol eliminates certain bacteria that cause tuberculosis (TB). It is used with other medicines to treat tuberculosis and to prevent you from giving the infection to others. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Ethambutol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Levoketoconazole Mercaptopurine Methotrexate Methotrexate Injection

5 Major 7 Moderate

All (12) Major (5) Moderate (7)

Major

Ethambutol Azathioprine Azasan An increased risk of hepatotoxicity Details Ethambutol Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Ethambutol Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Ethambutol Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ethambutol Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Ethambutol Aluminum Distearate Decreased ethambutol serum concentrations Details Ethambutol Aluminum Hydroxide AlternaGEL® Decreased ethambutol serum concentrations Details Ethambutol Bacillus Of Calmette And Guerin Vaccine, Live Reduced efficacy of intravesical treatment or vaccination Details Ethambutol Delamanid Increased ethambutol plasma concentrations Details Ethambutol Dihydroxyaluminum Aminoacetate Decreased ethambutol serum concentrations Details Ethambutol Dihydroxyaluminum Sodium Carbonate Decreased ethambutol serum concentrations Details Ethambutol Magaldrate Decreased ethambutol serum concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.