Ethynodiol

46 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Isotretinoin Lixisenatide Injection Colesevelam Penicillin V Potassium Meropenem Injection Bexarotene Topical

40 Major 6 Moderate

All (46) Major (40) Moderate (6)

Major

Ethynodiol Isotretinoin Absorica Explained Decreased effectiveness of hormonal contraceptives Details Ethynodiol Amoxicillin Amoxi Drop Reduced efficacy of oral contraceptive Details Ethynodiol Ampicillin Amcill® Decreased contraceptive effectiveness Details Ethynodiol Ampicillin Injection Omnipen-N® Decreased contraceptive effectiveness Details Ethynodiol Bexarotene Targretin Decreased contraceptive effectiveness Details Ethynodiol Bexarotene Topical Targretin Decreased contraceptive effectiveness Details Ethynodiol Cefaclor Ceclor® Decreased contraceptive effectiveness Details Ethynodiol Cefadroxil Duricef® Decreased contraceptive effectiveness Details Ethynodiol Cefdinir Omnicef® Decreased contraceptive effectiveness Details Ethynodiol Cefixime Suprax Decreased contraceptive effectiveness Details Ethynodiol Cefprozil Cefzil® Decreased contraceptive effectiveness Details Ethynodiol Ceftazidime Injection Fortaz Decreased contraceptive effectiveness Details Ethynodiol Cefuroxime Injection Kefurox® Decreased contraceptive effectiveness Details Ethynodiol Colesevelam Welchol Decreased contraceptive effectiveness Details Ethynodiol Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Ethynodiol Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Ethynodiol Dexamethasone Injection Decadron Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Ethynodiol Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive, increased risk of breakthrough bleeding and/o... Details Ethynodiol Doxycycline Injection Acticlate Reduced efficacy of oral contraceptive Details Ethynodiol Enasidenib Idhifa Reduced hormonal contraceptive exposure and reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleed... Details Ethynodiol Encorafenib Braftovi Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Ethynodiol Exenatide Injection Bydureon Reduced oral contraceptives absorption and reduced efficacy of oral contraceptives Details Ethynodiol Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Ethynodiol Hydrocortisone Ala-Cort Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Ethynodiol Hydrocortisone Injection A-Hydrocort® Altered (reduced/increased) hydrocortisone exposure, reduced efficacy of hydrocortisone and an increased risk of hydrocortisone-re... Details Ethynodiol Lixisenatide Injection Adlyxin® Decreased absorption of oral contraceptives Details Ethynodiol Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Ethynodiol Meropenem Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Ethynodiol Meropenem Injection Merrem® Reduced hormonal contraceptive exposure and an increased risk of contraceptive failure Details Ethynodiol Methylergonovine Methergine Increased methylergonovine exposure Details Ethynodiol Minocycline Amzeeq Decreased contraceptive efficacy Details Ethynodiol Minocycline Topical Amzeeq Decreased contraceptive efficacy Details Ethynodiol Mitapivat Aqvesme Reduced hormonal contraceptive exposure Details Ethynodiol Nafcillin Injection Unipen® Injection Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Ethynodiol Nevirapine Viramune Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and increased risk of breakthrough bleeding a... Details Ethynodiol Nifedipine Adalat® Increased NIFEdipine exposure Details Ethynodiol Octreotide Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Ethynodiol Octreotide Injection Bynfezia Decreased bioavailability and decreased efficacy of combined oral contraceptives or increased breakthrough bleeding Details Ethynodiol Penicillin G Procaine Injection Bactracillin G Decreased contraceptive effectiveness Details Ethynodiol Penicillin V Potassium Beepen-VK® Decreased contraceptive effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.