Etravirine and Digoxin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Etravirine
Digoxin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure and plasma concentrations of digoxin
Interaction Deep Dive
The mean AUC and Cmax of digoxin increased by approximately 19% and 18%, respectively, when coadministered with etravirine. For patients initiating a combination of etravirine and digoxin, the lowest dose of digoxin should be used. For patients on a stable digoxin regimen and initiating etravirine, no dose adjustment of either etravirine or digoxin is needed. Monitoring of digoxin serum concentrations is recommended1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) In a pharmacokinetic drug interaction study in 16 subjects receiving etravirine, coadministration of a single-dose of digoxin 0.5 mg increased the mean digoxin AUC ratio by 1.19 (90% confidence interval (CI), 0.96 to 1.49) and mean digoxin Cmax ratio by 1.18 (90% CI, 0.9 to 1.56) 1.
Common questions
Can I take Etravirine and Digoxin together?
Increased exposure and plasma concentrations of digoxin Always confirm with your pharmacist or prescriber before making any change.
How serious is the Etravirine and Digoxin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Etravirine or Digoxin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: INTELENCE(R) oral tablets, etravirine oral tablets. Tibotec, Inc. Raritan, NJ, 2009. DailyMed
Keep reading about Etravirine
Keep reading about Digoxin
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