Famotidine

217 interactions 460 cited references

Also sold as: Calmicid Fluxid® Pepcid Pepcid® Pepcid® AC Pepcid® RPD Zantac Reformulated Aug 2022

About Famotidine

Famotidine is an H2 blocker used to treat ulcers, acid reflux, heartburn, and conditions where the stomach produces too much acid. Read the full Famotidine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Pimozide Mesoridazine Dronedarone Levoketoconazole Cisapride

12 Contraindicated 189 Major 12 Moderate 4 Minor

All (217) Contraindicated (12) Major (189) Moderate (12) Minor (4)

Contraindicated

Famotidine Bepridil An increased risk of QT interval prolongation Details Famotidine Cisapride Propulsid® Increased risk of QT interval prolongation Details Famotidine Dronedarone Multaq Increased risk of QT interval prolongation Details Famotidine Levoketoconazole Recorlev An increased risk of QT interval prolongation, torsades de pointes and reduced levoketoconazole exposure Details Famotidine Mesoridazine An increased risk of QT interval prolongation Details Famotidine Pimozide Increased pimozide exposure, an increased risk of pimozide-related adverse reactions and an increased risk of QT interval prolonga... Details Famotidine Piperaquine An increased risk of QT interval prolongation Details Famotidine Saquinavir An increased risk of QT interval prolongation Details Famotidine Sparfloxacin An increased risk of QT interval prolongation Details Famotidine Terfenadine An increased risk of QT interval prolongation Details Famotidine Thioridazine An increased risk of QT interval prolongation Details Famotidine Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Famotidine Sertraline An increased risk of QT interval prolongation Details Famotidine Buprenorphine Belbuca An increased risk of QT interval prolongation Details Famotidine Relugolix Orgovyx Increased risk of QT interval prolongation Details Famotidine Acalabrutinib Calquence Reduced acalabrutinib exposure Details Famotidine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Famotidine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Famotidine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Famotidine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Famotidine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Famotidine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Famotidine Anagrelide Agrylin Increased risk of QT interval prolongation Details Famotidine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Famotidine Cefuroxime Ceftin® Decreased cefuroxime axetil exposure Details Famotidine Chloroquine Aralen® Increased risk of QT-interval prolongation Details Famotidine Dasatinib Phyrago Reduced dasatinib exposure and an increased risk of QT interval prolongation Details Famotidine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Famotidine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Famotidine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Famotidine Encorafenib Braftovi Increased risk of QT interval prolongation Details Famotidine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Famotidine Erlotinib Tarceva Reduced erlotinib exposure Details Famotidine Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Famotidine Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Famotidine Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Famotidine Amprenavir Decreased fosamprenavir absorption and reduction of amprenavir efficacy (active fosamprenavir metabolite) Details Famotidine Apomorphine Apokyn Increased risk of QT interval prolongation Details Famotidine Aripiprazole Abilify An increased risk of QT interval prolongation Details Famotidine Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.