Fenofibrate

16 interactions 2 explained in plain English
Also sold as: Antara Antara® Fenoglide Fenoglide® Fibricor Lipidil® Lipofen Lipofen® Tricor TriCor® Triglide® Trilipix Trilipix®
About Fenofibrate

Fenofibrate is used with a low-fat diet, exercise, and sometimes with other medications to reduce the amounts of fatty substances such as cholesterol and triglycerides in the blood and to increase the amount of HDL (high-density lipoprotein; a type of fatty substance that decreases the risk of heart disease) in the blo… Read the full Fenofibrate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Simvastatin Atorvastatin Cholestyramine Resin Colesevelam Colestipol
11 Major 5 Moderate
All (16) Major (11) Moderate (5)

Major

Fenofibrate Colchicine Colcrys Explained An increased risk of myopathy, including rhabdomyolysis Details Fenofibrate Simvastatin Flolipid Explained An increased risk of myopathy or rhabdomyolysis Details Fenofibrate Atorvastatin Atorvaliq An increased risk of myopathy or rhabdomyolysis Details Fenofibrate Cholestyramine Resin Locholest® Reduced absorption of fenofibrate Details Fenofibrate Colesevelam Welchol Reduced fenofibric acid effectiveness and reduced absorption of fenofibrate Details Fenofibrate Colestipol Colestid Reduced absorption of fenofibrate Details Fenofibrate Cyclosporine Injection Atopica An increased risk of nephrotoxicity with reduced creatine clearance and an increased risk of renal function deterioration Details Fenofibrate Cyclosporine Ophthalmic Cequa An increased risk of nephrotoxicity with reduced creatine clearance and an increased risk of renal function deterioration Details Fenofibrate Ezetimibe Zetia Increased ezetimibe exposure and an increased risk of cholelithiasis Details Fenofibrate Fluvastatin Lescol An increased risk of myopathy and rhabdomyolysis Details Fenofibrate Lovastatin Altocor® An increased risk of myopathy or rhabdomyolysis Details

Moderate

Fenofibrate Bempedoic Acid Nexletol An increased triglycerides and reduced high-density lipoprotein cholesterol (HDL-C) Details Fenofibrate Glimepiride Amaryl Increased glimepiride exposure and increased blood glucose lowering effect and risk of hypoglycemia Details Fenofibrate Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia Details Fenofibrate Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia Details Fenofibrate Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.