Feprazone and Amitriptyline: Interaction Details
AI-assisted, pharmacist-reviewed · AI content regenerated Jul 11, 2026 · Source data updated Jul 2, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Amitriptyline
Feprazone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
You've been prescribed amitriptyline (an antidepressant that also helps with mood, sleep, and nerve pain) along with feprazone, which is an anti-inflammatory pain medicine (an NSAID). When these two are taken together, they can raise your risk of bleeding. In rare cases this can include serious bleeding, such as bleeding in the brain.
This doesn't mean you can't take both, but it is worth being aware of. Watch for things like unusual bruising, bleeding gums, blood in your stool or urine, or a bad headache that won't go away. The good news is your care team can manage this by keeping a closer eye on you. Please check with your pharmacist or doctor if you have any concerns.
Effect: Increased bleeding risk, including intracranial hemorrhage, reported within 30 days of concomitant use.
Drugs: Amitriptyline (tricyclic antidepressant) plus feprazone (NSAID). Neither is a prodrug relevant here; the interaction is additive/pharmacodynamic on hemostasis.
- Mechanism: Unknown/unclear; likely additive effects on platelet function and mucosal integrity.
- Direction: Increased bleeding risk.
- Onset: Unspecified.
- Evidence: Established.
- Management: Use caution; monitor for signs of bleeding (GI bleed, bruising, neurologic changes). Consider gastroprotection or alternative analgesia per individual risk.
What happens
An increased risk of bleeding
Interaction Deep Dive
Exercise caution when NSAIDs and tricyclic antidepressants are administered together, because the combination may heighten the likelihood of bleeding, such as intracranial hemorrhage occurring within 30 days of joint use1. During concurrent therapy with an NSAID and a tricyclic antidepressant, observe the patient for indications of elevated bleeding.
Why it happens (mechanism)
Unknown
How to manage this interaction
Keep taking both medications as prescribed unless your prescriber tells you otherwise. This combination is used, but it calls for caution and closer attention.
- Your care team may monitor you more closely for signs of bleeding.
- Watch for and report: unusual bruising, bleeding gums or nose, blood in stool, urine, or vomit, black tarry stools, or a severe or persistent headache.
- Ask your pharmacist or doctor whether a safer pain-relief option might suit you, and mention any other blood thinners you take.
Bring up any concerns with your pharmacist or prescriber so your treatment can be tailored to you.
Management is individual — confirm any change with your pharmacist or prescriber.
Literature reports
1 report — tap to read
a) The combined use of NSAIDs and antidepressants, such as tricyclic antidepressants, SSRIs, serotonin-norepinephrine reuptake inhibitors, and MAOIs, led to a higher risk of intracranial hemorrhage within 30 days of concurrent use when compared with using an antidepressant by itself. No significant difference was found among the antidepressant drug classes with respect to this increased risk; however, male patients had an increased risk compared with female patients 1..
Common questions
Can I take Feprazone and Amitriptyline together?
Taking amitriptyline with feprazone can raise your bleeding risk, so watch for unusual bleeding or bruising and keep in touch with your care team, who can monitor you and adjust treatment if needed. Always confirm with your pharmacist or prescriber before making any change.
How serious is the Feprazone and Amitriptyline interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How is the Feprazone and Amitriptyline interaction managed?
Keep taking both medications as prescribed unless your prescriber tells you otherwise. This combination is used, but it calls for caution and closer attention. Your care team may monitor you more closely for signs of bleeding. Watch for and report: unusual bruising, bleeding gums or nose, blood in stool, urine, or vomit, black tarry stools, or a severe or persistent headache. Ask your pharmacist o… Management is individual — always follow your own care team's guidance.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Feprazone or Amitriptyline need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Shin JY, Park MJ, Lee SH, et al: Risk of intracranial haemorrhage in antidepressant users with concurrent use of non-steroidal anti-inflammatory drugs: nationwide propensity score matched study. BMJ 2015; 351:h3517. PubMed
Keep reading about Amitriptyline
Keep reading about Feprazone
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist