Fluvastatin and Delavirdine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Delavirdine
Fluvastatin
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased serum fluvastatin levels and an increased risk of myopathy or rhabdomyolysis
Interaction Deep Dive
Coadministration of cerivastatin and delavirdine has resulted development of rhabdomyolysis in 1 case report1. Concurrent administration of delavirdine with fluvastatin may lead to inhibition of CYP3A-mediated fluvastatin metabolism by delavirdine, resulting in increased serum fluvastatin levels and increased adverse effects. If delavirdine and fluvastatin are used concurrently, use lowest possible dose of fluvastatin and monitor patient for signs and symptoms of myopathy or rhabdomyolysis (muscle pain, tenderness, or weakness). Consider using alternatives to fluvastatin such as pravastatin 2.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated fluvastatin metabolism
Literature reports
1 report — tap to read
a) A 63-year-old HIV asymptomatic male developed rhabdomyolysis one month after beginning therapy with delavirdine and cerivastatin. The patient had well-controlled hypercholesterolemia, for which he had been receiving cerivastatin 20 mg daily for the last 5 years. He was receiving treatment with indinavir, lamivudine, and stavudine for HIV infection for the last 9 years. Two months before his hospital admission indinavir was substituted with delavirdine (400 mg every 8 hours). One month after beginning his new regimen, he developed a generalized malaise, with muscle pain in legs and lower back, nausea, vomiting and dark urine. He was diagnosed with acute renal failure and rhabdomyolysis. All medications were withheld and his enzyme levels were normal 4 weeks later. The author concludes that this patients acute renal failure (secondary to rhabdomyolysis) was likely to have been caused by the interaction between cerivastatin and delavirdine. Caution should be exercised when coadministering statins and protease inhibitors 1.
Common questions
Can I take Fluvastatin and Delavirdine together?
Increased serum fluvastatin levels and an increased risk of myopathy or rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Fluvastatin and Delavirdine interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Fluvastatin or Delavirdine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Castro J & Gutierrez L: Rhabdomyolysis with acute renal failure probably related to the interaction of atorvastatin and delavirdine. Am J Med 2002; 112:505. PubMed
- Product Information: RESCRIPTOR(R) oral tablets, delavirdine mesylate oral tablets. Pfizer,Inc, New York, NY, 2006.
Keep reading about Delavirdine
Keep reading about Fluvastatin
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