Fosfomycin

63 interactions 3 explained in plain English
Also sold as: Contepo Monurol® Sachet
About Fosfomycin

Fosfomycin is an antibiotic used to treat infections of the urinary tract. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Fosfomycin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Disopyramide Dolasetron Injection Degarelix Injection Oxaliplatin Injection Anagrelide Moxifloxacin Ophthalmic
62 Major 1 Moderate
All (63) Major (62) Moderate (1)

Major

Fosfomycin Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Fosfomycin Lefamulin Xenleta An increased risk of QT interval prolongation Details Fosfomycin Lenvatinib Lenvima An increased risk of QT interval prolongation Details Fosfomycin Levofloxacin Levaquin An increased risk of QT interval prolongation Details Fosfomycin Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Fosfomycin Mefloquine Lariam® An increased risk of QT interval prolongation Details Fosfomycin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Fosfomycin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Fosfomycin Metronidazole Flagyl An increased risk of QT interval prolongation Details Fosfomycin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Fosfomycin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Fosfomycin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Fosfomycin Moxifloxacin Avelox An increased risk of QT interval prolongation Details Fosfomycin Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Fosfomycin Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Fosfomycin Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Fosfomycin Octreotide Bynfezia An increased risk of QT interval prolongation Details Fosfomycin Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Fosfomycin Ofloxacin Floxin® An increased risk of QT interval prolongation Details Fosfomycin Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Fosfomycin Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Fosfomycin Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation Details

Moderate

Fosfomycin Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.