Furosemide Injection and Cisplatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Furosemide Injection
Cisplatin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased ototoxicity and an increased risk of nephrotoxicity
Interaction Deep Dive
Concomitant use of CISplatin and furosemide may result in an increased risk of ototoxicity and enhanced nephrotoxicity of cisplatin213. Therefore, administer furosemide at lower doses and with positive fluid balance when given for forced diuresis during CISplatin therapy. If CISplatin and furosemide are coadministered, monitoring renal function 21.
Why it happens (mechanism)
Additive or synergistic toxicity
Common questions
Can I take Furosemide Injection and Cisplatin together?
An increased ototoxicity and an increased risk of nephrotoxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Furosemide Injection and Cisplatin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Furosemide Injection or Cisplatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: LASIX® ONYU subcutaneous injection, furosemide subcutaneous injection. SQ Innovation, Inc (per manufacturer), Burlington, MA, 2025. DailyMed
- Product Information: FUROSCIX(R) subcutaneous injection, furosemide subcutaneous injection. scPharmaceuticals Inc (per FDA), Burlington, MA, 2025. DailyMed
- Product Information: PLATINOL(R) IV injection, cisplatin IV injection. Bristol-Myers Squibb Company, Princeton, NJ, 2010.
Keep reading about Furosemide Injection
Keep reading about Cisplatin
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