Gemfibrozil and Sulopenem: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Gemfibrozil
Sulopenem
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased sulopenem exposure and an increased risk of sulopenem-related adverse reactions
Interaction Deep Dive
Concomitant administration of sulopenem with OAT3 inhibitors may increase sulopenem exposure. If concomitant use of sulopenem is necessary, monitor more frequently for adverse reactions associated with sulopenem1.
Why it happens (mechanism)
Inhibition of OAT3-mediated efflux transport of sulopenem
Common questions
Can I take Gemfibrozil and Sulopenem together?
Increased sulopenem exposure and an increased risk of sulopenem-related adverse reactions Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gemfibrozil and Sulopenem interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Gemfibrozil or Sulopenem need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ORLYNVAH(TM) oral tablets, sulopenem etzadroxil and probenecid oral tablets. Iterum Therapeutics U.S. Limited (per FDA), Chicago, IL, 2024. DailyMed
Keep reading about Gemfibrozil
Keep reading about Sulopenem
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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