Glecaprevir and Lovastatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lovastatin
Glecaprevir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased lovastatin exposure and increased risk of myopathy
Interaction Deep Dive
Concurrent use of glecaprevir/pibrentasvir and lovastatin is not recommended. Coadministration may result in increased lovastatin plasma levels and increase the risk of myopathy, including rhabdomyolysis. In a pharmacokinetic study, when lovastatin 10 mg once daily was coadministered with glecaprevir 300 mg/pibrentasvir 120 mg once daily, lovastatin Cmax remained unchanged and AUC increased by 70%, while lovastatin acid Cmax increased by 473% and AUC increased by 310%1.
Why it happens (mechanism)
Unknown
Literature reports
1 report — tap to read
a) In a pharmacokinetic study (N=12), when lovastatin 10 mg once daily was coadministered with glecaprevir 300 mg/pibrentasvir 120 mg once daily, lovastatin Cmax remained unchanged and AUC increased by 70%; lovastatin acid Cmax increased by 473% and AUC increased by 310% 1.
Common questions
Can I take Glecaprevir and Lovastatin together?
Increased lovastatin exposure and increased risk of myopathy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glecaprevir and Lovastatin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Glecaprevir or Lovastatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: MAVYRET(R) oral tablets, oral pellets, glecaprevir pibrentasvir oral tablets, oral pellets. AbbVie Inc (per FDA), North Chicago, IL, 2023. DailyMed
Keep reading about Lovastatin
Keep reading about Glecaprevir
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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