Glipizide and Magnesium Carbonate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Glipizide
Magnesium Carbonate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hypoglycemia (CNS depression, seizures)
Interaction Deep Dive
The concomitant use of glipiZIDE or glyburide with magnesium hydroxide antacids has been reported to increase the AUC of the non-microniaz form of either drug123.
Why it happens (mechanism)
Increased rate/extent gastrointestinal absorption of glipiZIDE
Common questions
Can I take Glipizide and Magnesium Carbonate together?
Hypoglycemia (CNS depression, seizures) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glipizide and Magnesium Carbonate interaction?
It is rated minor. Usually limited clinical impact.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Glipizide or Magnesium Carbonate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (3)
- Neuvonen PJ & Kivisto KT: The effects of magnesium hydroxide on the absorption and efficacy of two glibenclamide preparations. Br J Clin Pharmacol 1991; 32:215-220. PubMed
- Kivisto KT & Neuvonen PJ: Enhancement of absorption and effect of glipizide by magnesium hydroxide. Clin Pharmacol Ther 1991; 49:39-43. DOI
- Boateng YA, Barber HE, MacDonald TM, et al: Disposition of gamma-glutamyl levodopa (gludopa) after intravenous bolus injection in healthy volunteers. Br J Clin Pharmacol 1991; 31:419-422. PubMed
Keep reading about Glipizide
Keep reading about Magnesium Carbonate
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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