Glucagon Injection / Solution and Thioridazine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Thioridazine
No brand names on recordGlucagon Injection / Solution
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of gastrointestinal side effects
Interaction Deep Dive
Concomitant use of glucagon as a diagnostic aid with anticholinergics is not recommended. Treatment with both glucagon and anticholinergics may increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility21.
Why it happens (mechanism)
Additive effects on inhibition of gastrointestinal motility
Common questions
Can I take Glucagon Injection / Solution and Thioridazine together?
Increased risk of gastrointestinal side effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glucagon Injection / Solution and Thioridazine interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Glucagon Injection / Solution or Thioridazine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: GVOKE subcutaneous injection, intravenous injection, glucagon subcutaneous injection, intravenous injection. Xeris Pharmaceuticals Inc (per FDA), Chicago, IL, 2025. DailyMed
- Product Information: GlucaGen(R) subcutaneous, intramuscular, intravenous injection, glucagon subcutaneous, intramuscular, intravenous injection. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2021. DailyMed
Keep reading about Thioridazine
Keep reading about Glucagon Injection / Solution
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