Granisetron Transdermal Patch and Mifepristone: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mifepristone
Granisetron Transdermal Patch
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Avoid coadministration of miFEPRIStone and other drugs that prolong QT interval as it may increase the risk of QT interval prolongation. MiFEPRIStone and its metabolites block IKr. MiFEPRIStone prolongs the QTc interval in a dose related manner. There is little or no experience with high exposure, concomitant dosing with other QT prolonging drugs, or potassium channel variants resulting in a long QT interval. To minimize risk, use the lowest effective dose. Wait at least 2 weeks after stopping miFEPRIStone before initiating drugs that prolong QT5.
Why it happens (mechanism)
Additive QT interval prolongation
Literature reports
6 reports — tap to read
a) Postmarketing cases of ECG changes have been reported with chloroquine use 6.
b) Both flecainide and miFEPRIStone have been associated with dose-dependent QT interval prolongation, and torsades de pointes has been reported during flecainide therapy 2. Prochlorperazine is a phenothiazine tranquilizer, and some drugs in this class have been associated with distortions of the QT interval 7.
c) QT prolongation and ventricular arrhythmias, including torsade de pointes, have been reported with ibutilide 1. Tetrabenazine has been associated with QT interval prolongation 3.
d) Octreotide has been associated with QT interval prolongation 4.
e) Protriptyline has been associated with QT interval prolongation and arrhythmias 8.
f) Sorafenib is a CYP3A4 substrate and competitive CYP3A4 inhibitor that has been associated with rare cases of QT interval prolongation 9.
Common questions
Can I take Granisetron Transdermal Patch and Mifepristone together?
An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Granisetron Transdermal Patch and Mifepristone interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Granisetron Transdermal Patch or Mifepristone need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (9)
- Product Information: ibutilide fumarate IV injection, ibutilide fumarate IV injection. Bioniche Pharma USA (per Manufacturer), Lake Forest, IL, 2009.
- Product Information: Flecainide acetate oral tablets, flecainide acetate oral tablets. Amneal Pharmaceuticals (DailyMed), Paterson, NJ, 2011. DailyMed
- Product Information: XENAZINE(R) oral tablets, tetrabenazine oral tablets. Lundbeck Inc. (per FDA), Deerfield, IL, 2011. DailyMed
- Product Information: Sandostatin LAR(R) Depot IM injectable suspension, octreotide acetate IM injectable suspension. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2011.
- Product Information: KORLYM(R) oral tablets, mifepristone oral tablets. Corcept Therapeutics Incorporated (per Dailmed), Redwood City, CA, 2024. DailyMed
- Product Information: chloroquine phosphate oral tablets, chloroquine phosphate oral tablets. West-ward Pharmaceutical Corp, Eatontown, NJ, 2009. DailyMed
- Product Information: prochlorperazine edisylate intramuscular intravenous injection, prochlorperazine edisylate intramuscular intravenous injection. Bedford Laboratories (per Manufacturer), Bedford, OH, 2011.
- Product Information: protriptyline hydrochloride oral tablets, protriptyline hydrochloride oral tablets. Boehringer Ingelheim Roxane Laboratories, Inc, Columbus, OH, 2009. DailyMed
- Product Information: NEXAVAR(R) oral tablets, sorafenib oral tablets. Bayer HealthCare Pharmaceuticals Inc (per manufacturer), Wayne, NJ, 2011. DailyMed
Keep reading about Mifepristone
Keep reading about Granisetron Transdermal Patch
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