Haloperidol
126 interactions 8 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
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Major
Haloperidol Diazepam Rectal Diastat Increased risk of CNS depression Details Haloperidol Diphenhydramine Injection Banophen Increased haloperidol exposure, an increased risk of haloperidol-related adverse events, including QTc interval prolongation and a... Details Haloperidol Diphenhydramine Topical Afterbite with Antihistamine Increased haloperidol exposure, an increased risk of haloperidol-related adverse events, including QTc interval prolongation and a... Details Haloperidol Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Haloperidol Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Haloperidol Dolasetron Anzemet An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Haloperidol Dolasetron Injection Anzemet An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Haloperidol Dronabinol Marinol Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Enasidenib Idhifa Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Encorafenib Braftovi Increased risk of QT interval prolongation Details Haloperidol Entrectinib Rozlytrek Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and an increased risk of QT interval prolo... Details Haloperidol Erdafitinib Balversa Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Eribulin Injection Halaven An increased risk of QT interval prolongation Details Haloperidol Esketamine Nasal Spray Spravato Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and an increased risk of CNS depression Details Haloperidol Esomeprazole Nexium Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Esomeprazole Injection Nexium Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Everolimus Afinitor Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Famotidine Calmicid An increased risk of QT interval prolongation Details Haloperidol Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Haloperidol Febuxostat Uloric Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Felbamate Felbatol An increased risk of QT interval prolongation Details Haloperidol Felodipine Plendil® Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Haloperidol Flecainide Tambocor® Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and an increased risk of QT interval prolo... Details Haloperidol Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Haloperidol Fostamatinib Tavalisse Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Fostemsavir Rukobia Increased risk of torsade de pointes Details Haloperidol Galantamine Razadyne An increased risk of QT interval prolongation Details Haloperidol Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Haloperidol Gefitinib Iressa Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Haloperidol Glasdegib Daurismo Increased risk of QT interval prolongation Details Haloperidol Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Haloperidol Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Haloperidol Granisetron Injection Granisol An increased risk of QT interval prolongation Details Haloperidol Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Haloperidol Hydralazine Apresoline® Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Haloperidol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Haloperidol Hydroxychloroquine Plaquenil Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and increased risk of QT interval prolonga... 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