Haloperidol

126 interactions 8 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Haloperidol Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Haloperidol Abametapir Explained Increased exposure of CYP3A4 substrate Details Haloperidol Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Haloperidol Sertraline Explained Increased haloperidol exposure and an increased risk of QT interval prolongation Details Haloperidol Buprenorphine Belbuca Explained An increased risk of QT interval prolongation and an increased risk of CNS and respiratory depression Details Haloperidol Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Haloperidol Dupilumab Injection Dupixent Explained Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Haloperidol Arsenic Trioxide Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Haloperidol Aripiprazole Injection Abilify An increased risk of QT interval prolongation and an increased risk of CNS depression Details Haloperidol Arsenic Trioxide Injection Trisenox Prolongation of the QTc interval and/or torsades de pointes Details Haloperidol Asciminib Scemblix Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Asenapine Transdermal Patch Secuado Increased haloperidol exposure, an increased risk of haloperidol-related adverse events, an increased risk of CNS depression and i... Details Haloperidol Azithromycin AzaSite Increased haloperidol exposure, an increased risk of haloperidol-related adverse effects and an increased risk of QT interval prol... Details Haloperidol Belumosudil Rezurock Explained Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Bicalutamide Casodex Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Cabergoline Dostinex® Loss of antiparkinson efficacy Details Haloperidol Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Haloperidol Alfuzosin UroXatral An increased risk of QT interval prolongation Details Haloperidol Alogliptin Nesina Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Amlodipine Amvaz® Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Anagrelide Agrylin Increased risk of QT interval prolongation Details Haloperidol Bedaquiline Sirturo Increased risk of QT interval prolongation Details Haloperidol Brodalumab Injection Siliq Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Haloperidol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Haloperidol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Haloperidol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Haloperidol Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Haloperidol Clotrimazole Aardora Anti-Fungal Maximum Strength Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Clotrimazole Lozenge Mycelex® Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Clotrimazole Topical Cruex Antifungal Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Cyclosporine Injection Atopica Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Cyclosporine Ophthalmic Cequa Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Dacomitinib Vizimpro Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Dasatinib Phyrago An increased risk of QT interval prolongation Details Haloperidol Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Haloperidol Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Haloperidol Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.