Haloperidol

Name: Haloperidol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

126 interactions 8 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Injection Ketoconazole Topical Metoclopramide Nasal Spray Amlodipine Oxaliplatin Injection Deutetrabenazine

3 Contraindicated 118 Major 5 Moderate

All (126) Contraindicated (3) Major (118) Moderate (5)

Moderate

Haloperidol Atorvastatin Atorvaliq Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Clonidine Transdermal Patch Catapres Induction or exacerbation of orthostatic regulation disturbances, increased arrhythmogenic potential and an increased risk of seda... Details Haloperidol Methyldopa Aldomet® CNS toxicity (dementia) or reversible parkinsonism Details Haloperidol Midazolam Nasal Spray Nayzilam An increased risk of CNS depression Details Haloperidol Midazolam Injection Nayzilam An increased risk of CNS depression Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.