Haloperidol

126 interactions 8 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Haloperidol Ibrexafungerp Brexafemme Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Haloperidol Istradefylline Nourianz Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Ivabradine Corlanor Increased risk of QT prolongation Details Haloperidol Labetalol Normodyne® Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Lacosamide Injection Motpoly An increased risk of CNS depression Details Haloperidol Lefamulin Xenleta Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and an increased risk of QT interval prolo... Details Haloperidol Lenacapavir Injection Sunlenca Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Lenacapavir Oral Sunlenca Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Haloperidol Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Haloperidol Levodopa Oral Inhalation Inbrija Loss of antiparkinson efficacy Details Haloperidol Levofloxacin Levaquin Increased risk of QT interval prolongation Details Haloperidol Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Haloperidol Linagliptin Tradjenta Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage and an increased risk of neurological t... Details Haloperidol Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Haloperidol Lumateperone Caplyta Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Lurasidone Latuda Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Haloperidol Metronidazole Flagyl An increased risk of QT interval prolongation Details Haloperidol Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Haloperidol Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Haloperidol Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Haloperidol Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Haloperidol Moxifloxacin Avelox Increased risk of QT interval prolongation Details Haloperidol Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Haloperidol Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Haloperidol Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Haloperidol Nicardipine Cardene Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Haloperidol Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsade de pointes, cardiac arrest) Details Haloperidol Ofloxacin Floxin® An increased risk of QT interval prolongation Details Haloperidol Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Haloperidol Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Haloperidol Olaparib Lynparza Increased haloperidol exposure and an increased risk of haloperidol-related adverse events, including QTc interval prolongation Details Haloperidol Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Haloperidol Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.