Ibrexafungerp and Ivosidenib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ivosidenib
Ibrexafungerp
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased ibrexafungerp exposure and loss of antifungal efficacy
Interaction Deep Dive
Do not administer ivosidenib (CYP3A4 inducer) with antifungal agents that are substrates of CYP3A4 (eg, ibrexafungerp) due to expected loss of antifungal efficacy1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of ibrexafungerp by ivosidenib
Common questions
Can I take Ibrexafungerp and Ivosidenib together?
Decreased ibrexafungerp exposure and loss of antifungal efficacy Always confirm with your pharmacist or prescriber before making any change.
How serious is the Ibrexafungerp and Ivosidenib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Ibrexafungerp or Ivosidenib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TIBSOVO(R) oral tablets, ivosidenib oral tablets. Servier Pharmaceuticals LLC (per FDA), Boston, MA, 2022. DailyMed
Keep reading about Ivosidenib
Keep reading about Ibrexafungerp
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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