Ibuprofen

302 interactions 942 cited references

Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen

About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal

4 Contraindicated 235 Major 63 Moderate

All (302) Contraindicated (4) Major (235) Moderate (63)

Major

Ibuprofen Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Heparin An increased risk of bleeding Details Ibuprofen Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Ibuprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Abciximab An increased risk of bleeding Details Ibuprofen Aceclofenac Increased risk of bleeding Details Ibuprofen Acemetacin Increased risk of bleeding Details Ibuprofen Acenocoumarol An increased risk of bleeding Details Ibuprofen Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ibuprofen Amineptine An increased risk of bleeding Details Ibuprofen Amitriptylinoxide An increased risk of bleeding Details Ibuprofen Amoxapine An increased risk of bleeding Details Ibuprofen Amtolmetin Guacil Increased risk of bleeding Details Ibuprofen Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Ibuprofen Ardeparin An increased risk of bleeding Details Ibuprofen Argatroban An increased risk of bleeding Details Ibuprofen Balsalazide Colazal Increased risk of bleeding Details Ibuprofen Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Bemiparin An increased risk of bleeding Details Ibuprofen Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Ibuprofen Bivalirudin Angiomax An increased risk of bleeding Details Ibuprofen Bromfenac Bromsite Increased risk of bleeding Details Ibuprofen Bufexamac Increased risk of bleeding Details Ibuprofen Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Cangrelor Kengreal An increased risk of bleeding Details Ibuprofen Carbamazepine Carbatrol Increased carBAMazepine exposure and increased carBAMazepine-related adverse events Details Ibuprofen Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Ibuprofen Certoparin An increased risk of bleeding Details Ibuprofen Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Ibuprofen Choline Salicylate Increased risk of bleeding Details Ibuprofen Cilostazol Pletal® An increased risk of bleeding Details Ibuprofen Citalopram Celexa An increased risk of bleeding Details Ibuprofen Clomipramine Anafranil An increased risk of bleeding Details Ibuprofen Clonixin Increased risk of bleeding Details Ibuprofen Clopamide Reduced diuretic effectiveness and possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.