Ibuprofen

302 interactions 942 cited references
Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen
About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal
4 Contraindicated 235 Major 63 Moderate
All (302) Contraindicated (4) Major (235) Moderate (63)

Moderate

Ibuprofen Nadolol Corgard Reduced antihypertensive effect Details Ibuprofen Nebivolol Bystolic Reduced antihypertensive effect Details Ibuprofen Norfloxacin An increased risk of seizures Details Ibuprofen Ofloxacin Floxin® An increased risk of seizures Details Ibuprofen Olmesartan Benicar Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Oxprenolol Reduced antihypertensive effect Details Ibuprofen Penbutolol Levatol® Reduced antihypertensive effect Details Ibuprofen Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Pindolol Visken® Reduced antihypertensive effect Details Ibuprofen Pralatrexate Increased pralatrexate exposure Details Ibuprofen Propranolol Hemangeol Reduced antihypertensive effect Details Ibuprofen Quinapril Accupril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Ramipril Altace Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Sotalol Betapace Reduced antihypertensive effect Details Ibuprofen Spirapril Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Telmisartan Micardis Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Timolol Betimol Reduced antihypertensive effect Details Ibuprofen Trandolapril Mavik® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Valsartan Diovan Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Ibuprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Ibuprofen Levofloxacin Injection Levaquin An increased risk of seizures Details Ibuprofen Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Ibuprofen Ofloxacin Otic Floxin® Otic An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.