Ibuprofen

302 interactions 942 cited references

Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen

About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal

4 Contraindicated 235 Major 63 Moderate

All (302) Contraindicated (4) Major (235) Moderate (63)

Major

Ibuprofen Cyclopenthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Cyclosporine Atopica An increased risk of cycloSPORINE nephrotoxicity Details Ibuprofen Cyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Dalteparin Fragmin An increased risk of bleeding Details Ibuprofen Danaparoid An increased risk of bleeding Details Ibuprofen Desipramine Norpramin An increased risk of bleeding Details Ibuprofen Desirudin Iprivask An increased risk of bleeding Details Ibuprofen Desvenlafaxine Pristiq An increased risk of bleeding Details Ibuprofen Deutivacaftor Increased CYP2C9 substrate exposure Details Ibuprofen Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Dexibuprofen Increased risk of bleeding Details Ibuprofen Dexketoprofen Increased risk of bleeding Details Ibuprofen Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Dibenzepin An increased risk of bleeding Details Ibuprofen Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Ibuprofen Diflunisal Dolobid Increased risk of bleeding Details Ibuprofen Dipyrone Increased risk of bleeding Details Ibuprofen Dothiepin An increased risk of bleeding Details Ibuprofen Doxepin Prudoxin An increased risk of bleeding Details Ibuprofen Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Ibuprofen Droxicam Increased risk of bleeding Details Ibuprofen Duloxetine An increased risk of bleeding Details Ibuprofen Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ibuprofen Eptifibatide An increased risk of bleeding Details Ibuprofen Escitalopram Lexapro An increased risk of bleeding Details Ibuprofen Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Etofenamate Increased risk of bleeding Details Ibuprofen Etoricoxib Increased risk of bleeding Details Ibuprofen Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Felbinac Increased risk of bleeding Details Ibuprofen Fepradinol Increased risk of bleeding Details Ibuprofen Feprazone Increased risk of bleeding Details Ibuprofen Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Ibuprofen Floctafenine Increased risk of bleeding Details Ibuprofen Fluconazole Diflucan Increased NSAIDs exposure and an increased risk of NSAIDs-related adverse reactions Details Ibuprofen Flufenamic Acid Increased risk of bleeding Details Ibuprofen Fluoxetine RECONCILE An increased risk of bleeding Details Ibuprofen Fluvoxamine An increased risk of bleeding Details Ibuprofen Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Gossypol Increased risk of adverse gastrointestinal effects Details

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