Ibuprofen

302 interactions 942 cited references

Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen

About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal

4 Contraindicated 235 Major 63 Moderate

All (302) Contraindicated (4) Major (235) Moderate (63)

Major

Ibuprofen Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Iloprost Aurlumyn An increased risk of bleeding Details Ibuprofen Imipramine An increased risk of bleeding Details Ibuprofen Indapamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Indomethacin Indocin An increased risk of gastrointestinal toxicity Details Ibuprofen Inotersen Increased risk of bleeding Details Ibuprofen Ketoprofen Actron® An increased risk of gastrointestinal toxicity Details Ibuprofen Lepirudin An increased risk of bleeding Details Ibuprofen Levomilnacipran An increased risk of bleeding Details Ibuprofen Lithium Increased lithium exposure and an increased risk of lithium toxicity Details Ibuprofen Lofepramine An increased risk of bleeding Details Ibuprofen Lornoxicam An increased risk of gastrointestinal toxicity Details Ibuprofen Loxoprofen An increased risk of gastrointestinal toxicity Details Ibuprofen Lumacaftor Reduced ibuprofen exposure Details Ibuprofen Lumiracoxib An increased risk of gastrointestinal toxicity Details Ibuprofen Meadowsweet Increased risk of bleeding Details Ibuprofen Meclofenamate Meclodium® An increased risk of gastrointestinal toxicity Details Ibuprofen Mefenamic Acid Ponstel® An increased risk of gastrointestinal toxicity Details Ibuprofen Melatonin An increased risk of suppression of endogenous melatonin levels Details Ibuprofen Melitracen An increased risk of bleeding Details Ibuprofen Meloxicam Alloxate An increased risk of gastrointestinal toxicity Details Ibuprofen Melphalan Alkeran An increased risk of bleeding Details Ibuprofen Mesalamine Apriso An increased risk of gastrointestinal toxicity Details Ibuprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ibuprofen Methyclothiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Methylprednisolone Depo-Medrol Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Metolazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Milnacipran Savella An increased risk of bleeding Details Ibuprofen Morniflumate An increased risk of gastrointestinal toxicity Details Ibuprofen Nabumetone Relafen An increased risk of gastrointestinal toxicity Details Ibuprofen Nadroparin An increased risk of bleeding Details Ibuprofen Naproxen Aleve An increased risk of gastrointestinal toxicity Details Ibuprofen Nefazodone An increased risk of bleeding Details Ibuprofen Nepafenac Ilevro An increased risk of gastrointestinal toxicity Details Ibuprofen Niflumic Acid An increased risk of gastrointestinal toxicity Details Ibuprofen Nimesulide An increased risk of gastrointestinal toxicity Details Ibuprofen Nimesulide Beta Cyclodextrin An increased risk of gastrointestinal toxicity Details Ibuprofen Nortriptyline An increased risk of bleeding Details Ibuprofen Olsalazine Sodium An increased risk of gastrointestinal toxicity Details

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