Ibuprofen

302 interactions 942 cited references

Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen

About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal

4 Contraindicated 235 Major 63 Moderate

All (302) Contraindicated (4) Major (235) Moderate (63)

Major

Ibuprofen Opipramol An increased risk of bleeding Details Ibuprofen Oxaprozin Coxanto An increased risk of gastrointestinal toxicity Details Ibuprofen Oxyphenbutazone An increased risk of gastrointestinal toxicity Details Ibuprofen Parecoxib An increased risk of gastrointestinal toxicity Details Ibuprofen Parnaparin An increased risk of bleeding Details Ibuprofen Paroxetine Paxil An increased risk of bleeding Details Ibuprofen Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Ibuprofen Pentosan Polysulfate Sodium An increased risk of bleeding Details Ibuprofen Pentoxifylline Pentoxil® An increased risk of bleeding Details Ibuprofen Phenindione An increased risk of bleeding Details Ibuprofen Phenprocoumon An increased risk of bleeding Details Ibuprofen Phenylbutazone Equi-Phar An increased risk of gastrointestinal toxicity Details Ibuprofen Piketoprofen An increased risk of gastrointestinal toxicity Details Ibuprofen Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Piroxicam Feldene An increased risk of gastrointestinal toxicity Details Ibuprofen Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Ibuprofen Pranoprofen An increased risk of gastrointestinal toxicity Details Ibuprofen Prasugrel Effient An increased risk of bleeding Details Ibuprofen Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Ibuprofen Proglumetacin An increased risk of gastrointestinal toxicity Details Ibuprofen Propyphenazone An increased risk of gastrointestinal toxicity Details Ibuprofen Proquazone An increased risk of gastrointestinal toxicity Details Ibuprofen Protein C Ceprotin An increased risk of bleeding Details Ibuprofen Protriptyline An increased risk of bleeding Details Ibuprofen Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Reviparin An increased risk of bleeding Details Ibuprofen Rivaroxaban Xarelto An increased risk of bleeding Details Ibuprofen Rofecoxib An increased risk of gastrointestinal toxicity Details Ibuprofen Salicylic Acid An increased risk of gastrointestinal toxicity Details Ibuprofen Salsalate Disalcid An increased risk of gastrointestinal toxicity Details Ibuprofen Selexipag Uptravi An increased risk of bleeding Details Ibuprofen Sibutramine An increased risk of bleeding Details Ibuprofen Sodium Salicylate An increased risk of gastrointestinal toxicity Details Ibuprofen Sparsentan Filspari An increased risk of kidney injury, reduced CYP2C9 substrate exposure and reduced CYP2C9 substrate efficacy Details Ibuprofen Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ibuprofen Sulfasalazine Azulfidine An increased risk of gastrointestinal toxicity Details Ibuprofen Sulfinpyrazone An increased risk of bleeding Details Ibuprofen Sulindac Clinoril® An increased risk of gastrointestinal toxicity Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.