Ibuprofen

302 interactions 942 cited references

Also sold as: Addaprin Addaprin® Advil Caldolor Cedaprin® Counteract IB dvil® Genpril I-Prin® Ibu Ibuprohm Midol® Motrin Motrin® Motrin® IB Neoprofen NeoProfen® Profen IB® Proprinal Proprinal® Samson 8 Ultraprin® Wal-Profen

About Ibuprofen

Ibuprofen is an NSAID used to relieve pain, fever, and inflammation from conditions like arthritis and headaches. Read the full Ibuprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Nasal Spray Ketorolac Ophthalmic Ketorolac Ketorolac Injection Pemetrexed Injection Aspirin Rectal

4 Contraindicated 235 Major 63 Moderate

All (302) Contraindicated (4) Major (235) Moderate (63)

Major

Ibuprofen Sulodexide An increased risk of bleeding Details Ibuprofen Tacrolimus Astagraf Acute renal failure Details Ibuprofen Tegafur Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Ibuprofen Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ibuprofen Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details Ibuprofen Tenoxicam An increased risk of gastrointestinal toxicity Details Ibuprofen Tianeptine An increased risk of bleeding Details Ibuprofen Tiaprofenic Acid An increased risk of gastrointestinal toxicity Details Ibuprofen Ticagrelor Brilinta An increased risk of bleeding Details Ibuprofen Ticlopidine Ticlid® An increased risk of bleeding Details Ibuprofen Tinzaparin An increased risk of bleeding Details Ibuprofen Tirofiban An increased risk of bleeding Details Ibuprofen Tolfenamic Acid An increased risk of gastrointestinal toxicity Details Ibuprofen Tolmetin Tolectin 600 An increased risk of gastrointestinal toxicity Details Ibuprofen Torsemide Soaanz Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Trazodone Raldesy An increased risk of bleeding Details Ibuprofen Treprostinil Orenitram An increased risk of bleeding Details Ibuprofen Triamterene Dyrenium Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Ibuprofen Trichlormethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Trimipramine An increased risk of bleeding Details Ibuprofen Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details Ibuprofen Valdecoxib An increased risk of gastrointestinal toxicity Details Ibuprofen Venlafaxine An increased risk of bleeding Details Ibuprofen Vilazodone Viibryd An increased risk of bleeding Details Ibuprofen Vorapaxar Zontivity An increased risk of bleeding Details Ibuprofen Voriconazole Vfend Increased NSAIDs exposure Details Ibuprofen Vortioxetine Trintellix An increased risk of bleeding Details Ibuprofen Warfarin Coumadin An increased risk of bleeding Details Ibuprofen Xipamide Reduced diuretic effectiveness and possible nephrotoxicity Details Ibuprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Ibuprofen Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity Details Ibuprofen Melphalan Injection Alkeran An increased risk of bleeding Details Ibuprofen Mesalamine Rectal Canasa An increased risk of gastrointestinal toxicity Details Ibuprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ibuprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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