Indecainide and Digoxin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Digoxin
Indecainide
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Digoxin toxicity (nausea, vomiting, arrhythmias)
Interaction Deep Dive
Concomitant indecainide and digoxin therapy produced an increase in digoxin levels in 3 patients1.
Why it happens (mechanism)
Altered digoxin clearance
Literature reports
1 report — tap to read
a) Concomitant digoxin and indecainide therapy may result in increased digoxin plasma levels 1. During a randomized, double-blind parallel study with placebo control, indecainide was compared with quinidine; five indecainide-treated patients were also receiving digoxin. Digoxin plasma concentrations were determined in 4 patients before and after indecainide therapy. In 3 patients, the mean increase of digoxin was 201% (range, 47% to 300%). It was also noted that once indecainide was discontinued, the digoxin concentrations decreased significantly.
Common questions
Can I take Indecainide and Digoxin together?
Digoxin toxicity (nausea, vomiting, arrhythmias) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Indecainide and Digoxin interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Indecainide or Digoxin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Giardina EGV, Zaim S, Saroff AL, et al: Indecainide compared with quinidine for chronic stable ventricular arrhythmias secondary to coronary artery disease or to cardiomyopathy. Am J Cardiol 1987; 60:584-589. PubMed
Keep reading about Digoxin
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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