Indomethacin

95 interactions 5 explained in plain English
Also sold as: Indocin Indocin® Tivorbex Tivorbex®
About Indomethacin

Indomethacin is an NSAID used to relieve pain, swelling, and stiffness from arthritis and other inflammatory joint conditions. Read the full Indomethacin drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ophthalmic Ketorolac Injection Ketorolac Nasal Spray Ketorolac Epoprostenol Pemetrexed Injection
4 Contraindicated 55 Major 34 Moderate 2 Minor
All (95) Contraindicated (4) Major (55) Moderate (34) Minor (2)

Major

Indomethacin Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Indomethacin Meclofenamate Meclodium® Increased risk of bleeding Details Indomethacin Mefenamic Acid Ponstel® Increased risk of bleeding Details Indomethacin Meloxicam Alloxate Increased risk of bleeding Details Indomethacin Meloxicam Injection Alloxate Increased risk of bleeding Details Indomethacin Melphalan Alkeran An increased risk of bleeding Details Indomethacin Melphalan Injection Alkeran An increased risk of bleeding Details Indomethacin Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Indomethacin Mesalamine Apriso Increased risk of bleeding Details Indomethacin Mesalamine Rectal Canasa Increased risk of bleeding Details Indomethacin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Indomethacin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Indomethacin Nabumetone Relafen Increased risk of bleeding Details Indomethacin Naproxen Aleve Increased risk of bleeding Details Indomethacin Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.