Irinotecan Injection

96 interactions 769 cited references

Also sold as: Camptosar Camptosar® Onivyde

About Irinotecan Injection

Irinotecan is used alone or in combination with other medications to treat colon or rectal cancer (cancer that begins in the large intestine). Irinotecan is in a class of antineoplastic medications called topoisomerase I inhibitors. It works by stopping the growth of cancer cells. Read the full Irinotecan Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine Typhoid Vaccine Varicella Virus Vaccine, Live Yellow Fever Vaccine Atazanavir

14 Contraindicated 73 Major 9 Moderate

All (96) Contraindicated (14) Major (73) Moderate (9)

Contraindicated

Irinotecan Injection Atazanavir Reyataz Increased irinotecan and its active metabolite, SN-38 exposure Details Irinotecan Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Cobicistat Tybost Increased irinotecan exposure and an risk of increased irinotecan active metabolite exposure Details Irinotecan Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Ensitrelvir Increased CYP3A/BCRP substrate exposure and an increased risk of adverse reactions Details Irinotecan Injection Itraconazole Sporanox Increased irinotecan exposure Details Irinotecan Injection Ketoconazole Extina Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Irinotecan Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Irinotecan Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Irinotecan Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Irinotecan Injection Abametapir Increased exposure of CYP3A4 substrate Details Irinotecan Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Apalutamide Erleada Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Irinotecan Injection Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Irinotecan Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Irinotecan Injection Boceprevir Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Irinotecan Injection Capmatinib Tabrecta Increased BCRP substrate exposure and an increased risk of adverse reactions Details Irinotecan Injection Carbamazepine Carbatrol Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Irinotecan Injection Ceritinib Zykadia Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Irinotecan Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Irinotecan Injection Clarithromycin Biaxin Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Irinotecan Injection Conivaptan Vaprisol Increased CYP3A substrate exposure Details Irinotecan Injection Danicopan Voydeya Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effect Details Irinotecan Injection Darolutamide Nubeqa Increased plasma concentrations of BCRP substrates Details Irinotecan Injection Darunavir Increased irinotecan exposure and an increased risk of irinotecan-related adverse events Details Irinotecan Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Injection Eltrombopag Alvaiz Increased irinotecan exposure and an increased risk of irinotecan-related adverse reactions Details Irinotecan Injection Enasidenib Idhifa Increased exposure of BCRP substrate Details Irinotecan Injection Enzalutamide Xtandi Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Irinotecan Injection Erythromycin Erythrocin Stearate Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse effects Details Irinotecan Injection Fedratinib Inrebic Increased CYP3A4 substrate exposure Details Irinotecan Injection Fexinidazole An increased CYP3A4 substrate exposure Details Irinotecan Injection Fosnetupitant Increased exposure to chemotherapy agent and increased risk of side effects Details Irinotecan Injection Fosphenytoin Cerebyx Reduced irinotecan exposure and reduced irinotecan active metabolite exposure Details Irinotecan Injection Gemfibrozil Lopid Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.