Irinotecan Injection and Asciminib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Irinotecan Injection
Asciminib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects
Interaction Deep Dive
Concomitant use of asciminib (BCRP inhibitor) with BCRP substrates may increase BCRP substrates exposure, which may increase the risk of adverse reactions of these substrates. Closely monitor for adverse reactions in patients treated with asciminib at all recommended doses with concomitant use of BCRP substrates. Reduce the dosage of BCRP substrate as recommended when used concomitantly with asciminib at all recommended doses1.
Why it happens (mechanism)
Inhibition of BCRP-mediated efflux transport by asciminib
Common questions
Can I take Irinotecan Injection and Asciminib together?
Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Always confirm with your pharmacist or prescriber before making any change.
How serious is the Irinotecan Injection and Asciminib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Irinotecan Injection or Asciminib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: SCEMBLIX® oral tablets, asciminib oral tablets. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2025. DailyMed
Keep reading about Irinotecan Injection
Keep reading about Asciminib
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