Irinotecan Lipid Complex Injection

73 interactions 335 cited references
Also sold as: Onivyde® Onpattro
About Irinotecan Lipid Complex Injection

Irinotecan lipid complex is used in combination with other medications to treat pancreatic cancer that has spread to other parts of the body that has worsened after treatment with other chemotherapy medications. Irinotecan lipid complex is in a class of antineoplastic medications called topoisomerase I inhibitors. It w… Read the full Irinotecan Lipid Complex Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Yellow Fever Vaccine Ketoconazole Itraconazole Ensitrelvir Atazanavir Dengue Tetravalent Vaccine, Live
13 Contraindicated 55 Major 5 Moderate
All (73) Contraindicated (13) Major (55) Moderate (5)

Contraindicated

Irinotecan Lipid Complex Injection Atazanavir Reyataz Increased irinotecan and its active metabolite, SN-38 exposure Details Irinotecan Lipid Complex Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Ensitrelvir Increased CYP3A/BCRP substrate exposure and an increased risk of adverse reactions Details Irinotecan Lipid Complex Injection Itraconazole Sporanox Increased irinotecan exposure Details Irinotecan Lipid Complex Injection Ketoconazole Extina Increased irinotecan exposure and an increased irinotecan active metabolite exposure Details Irinotecan Lipid Complex Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Irinotecan Lipid Complex Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

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