Istradefylline

Major

Istradefylline Lumacaftor Decreased istradefylline exposure Details Istradefylline Mavorixafor Xolremdi Increased mavorixafor exposure and an increased risk of mavorixafor-related adverse effects Details Istradefylline Meperidine Demerol Increased meperidine exposure and risk of increased or prolonged opioid effects Details Istradefylline Methylergonovine Methergine Increased methylergonovine exposure Details Istradefylline Mifepristone Korlym Increased CYP3A4 substrate exposure and an increased miFEPRIStone exposure Details Istradefylline Mitotane Lysodren Decreased istradefylline exposure Details Istradefylline Morphine Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Istradefylline Morphine Sulfate Liposome Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Istradefylline Nefazodone Increased istradefylline exposure Details Istradefylline Nelfinavir Viracept Increased istradefylline exposure Details Istradefylline Nifedipine Adalat® Increased NIFEdipine exposure Details Istradefylline Omaveloxolone Skyclarys Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Istradefylline Paclitaxel Abraxane Increased PACLitaxel exposure Details Istradefylline Paclitaxel Protein-Bound Increased PACLitaxel exposure Details Istradefylline Phenobarbital Fidoquel Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Istradefylline Phenytoin Dilantin Decreased istradefylline exposure Details Istradefylline Pimozide Increased pimozide exposure Details Istradefylline Posaconazole Noxafil Increased istradefylline exposure and an increased posaconazole exposure Details Istradefylline Primidone Mysoline Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Istradefylline Ranolazine Aspruzyo Increased ranolazine exposure and an increased risk of ranolazine-related adverse effects Details Istradefylline Relacorilant Lifyorli Increased CYP3A4 substrate exposure and an increased risk of CYP3A4-substrate-related adverse reactions Details Istradefylline Repotrectinib Augtyro Increased repotrectinib exposure and an increased risk of repotrectinib-related adverse effects Details Istradefylline Ribociclib Kisqali Increased istradefylline exposure Details Istradefylline Rifampin Rifadin Decreased istradefylline exposure Details Istradefylline Ritonavir Norvir Increased istradefylline exposure Details Istradefylline Roflumilast Daliresp Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Istradefylline Saquinavir Increased istradefylline exposure Details Istradefylline St John's Wort Decreased istradefylline exposure Details Istradefylline Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Istradefylline Telaprevir Increased istradefylline exposure Details Istradefylline Telithromycin Increased istradefylline exposure Details Istradefylline Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Istradefylline Venetoclax Venclexta Increased venetoclax exposure and an increased risk of venetoclax toxicities including the risk of tumor lysis syndrome Details Istradefylline Viloxazine Qelbree Increased exposure of the CYP1A2 substrate and risk of adverse events Details Istradefylline Voriconazole Vfend Increased istradefylline exposure, an increased istradefylline-related adverse reactions, an increased voriconazole exposure and a... Details Istradefylline Ketoconazole Topical Extina® Foam Increased istradefylline exposure Details Istradefylline Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Istradefylline Morphine Injection Astramorph® PF Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details

Moderate

Istradefylline Dofetilide Tikosyn Increased dofetilide exposure Details Istradefylline Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details