Istradefylline
87 interactions 295 cited referencesIstradefylline is used along with the combination of levodopa and carbidopa (Duopa, Rytary, Sinemet, others) to treat "off" episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in people with Parkinson's disease (PD; a disorder of the nervous system that caus… Read the full Istradefylline drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Moderate
Istradefylline Dofetilide Tikosyn Increased dofetilide exposure Details Istradefylline Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Istradefylline Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Istradefylline Cannabis Reduced CYP1A2 substrate exposure Details Istradefylline Kratom Increased CYP3A substrate exposure Details Istradefylline Lumefantrine Increased artemether/lumefantrine exposure and an increased risk of potentiated QT prolongation Details Istradefylline Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Istradefylline Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details Istradefylline Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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