Istradefylline

Name: Istradefylline Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

87 interactions 295 cited references

Also sold as: Nourianz Nourianz®

About Istradefylline

Istradefylline is used along with the combination of levodopa and carbidopa (Duopa, Rytary, Sinemet, others) to treat "off" episodes (times of difficulty moving, walking, and speaking that may happen as medication wears off or at random) in people with Parkinson's disease (PD; a disorder of the nervous system that caus… Read the full Istradefylline drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Colchicine Indinavir Lefamulin Morphine Injection Itraconazole

2 Contraindicated 76 Major 9 Moderate

All (87) Contraindicated (2) Major (76) Moderate (9)

Contraindicated

Istradefylline Colchicine Colcrys Increased colchicine exposure and an increased risk of fatal toxicity Details Istradefylline Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.