Itraconazole
206 interactions 14 explained in plain English
Also sold as:
Sporanox
Tolsura
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Nisoldipine
Disopyramide
Lovastatin
Dihydroergotamine Injection
Finerenone
Irinotecan Lipid Complex Injection
Major
Itraconazole Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure, increased or prolonged opioid effects (CNS depression, respiratory depression) Details Itraconazole Fexofenadine Allegra Increased P-gp substrate exposure and an increased risk of P-gp substrate-related adverse effects Details Itraconazole Flecainide Tambocor® An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Itraconazole Fostamatinib Tavalisse Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Fostemsavir Rukobia Increased fostemsavir exposure and an increased risk of QT interval prolongation Details Itraconazole Futibatinib Lytgobi Increased futibatinib exposure and increased risk of futibatinib-related adverse reactions Details Itraconazole Galantamine Razadyne Increased galantamine exposure and an increased risk of galantamine-related adverse effects Details Itraconazole Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Gefitinib Iressa Increased gefitinib exposure and an increased risk of gefitinib-related adverse effects Details Itraconazole Gemifloxacin Factive An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Gilteritinib Xospata Increased gilteritinib plasma concentrations Details Itraconazole Glasdegib Daurismo Increased glasdegib concentration and increased risk of QTc interval prolongation Details Itraconazole Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Itraconazole Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Granisetron Injection Granisol An increased risk of QT interval prolongation and torsade de pointes Details Itraconazole Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Itraconazole Hydrocortisone Ala-Cort Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Hydrocortisone Injection A-Hydrocort® Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Itraconazole Ibrexafungerp Brexafemme Increased ibrexafungerp exposure Details Itraconazole Ibrutinib Imbruvica Increased ibrutinib exposure Details Itraconazole Ifosfamide Injection Ifex Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Infigratinib Truseltiq Increased infigratinib plasma concentrations Details Itraconazole Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Itraconazole Isradipine DynaCirc® An increased risk of congestive heart failure Details Itraconazole Istradefylline Nourianz Increased istradefylline exposure Details Itraconazole Ixabepilone Injection IXEMPRA Increased ixabepilone exposure and increase in the incidence and severity of adverse reactions Details Itraconazole Ixazomib Ninlaro Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects Details Itraconazole Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions and an increased risk of QT interval prolon... Details Itraconazole Leniolisib Joenja Increased leniolisib exposure Details Itraconazole Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Itraconazole Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Itraconazole Levofloxacin Levaquin Increased risk of QT interval prolongation Details Itraconazole Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Itraconazole Levonorgestrel After banger Increased levonorgestrel exposure Details Itraconazole Levonorgestrel Intrauterine System Kyleena Increased levonorgestrel exposure Details Itraconazole Linagliptin Tradjenta Increased CYP3A4/P-gp substrate exposure and an increased risk of CYP3A4/P-gp substrate-related adverse effects Details Itraconazole Loperamide Diamode An increased risk of QT interval prolongation, an increased risk of other ventricular arrhythmias, cardiac arrest, an increased lo... Details Itraconazole Loratadine Agistam® Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse effects DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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