Ivabradine and Crizotinib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Crizotinib
Ivabradine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of ivabradine and increased risk of QT prolongation
Interaction Deep Dive
Avoid concomitant use of ivabradine (CYP3A4 substrate) with a moderate CYP3A4 inhibitor that also prolongs the QT interval due to the potential for increased ivabradine exposure and additive QT prolongation1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of ivabradine and additive QT-interval prolongation
Common questions
Can I take Ivabradine and Crizotinib together?
Increased exposure of ivabradine and increased risk of QT prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Ivabradine and Crizotinib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Ivabradine or Crizotinib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: CORLANOR(R) oral tablets, ivabradine oral tablets. Amgen Inc. (per Manufacturer), Thousand Oaks, CA, 2015. DailyMed
Keep reading about Crizotinib
Keep reading about Ivabradine
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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