Ivabradine

275 interactions 1 explained in plain English 403 cited references

Also sold as: Corlanor Corlanor®

About Ivabradine

Ivabradine is used to treat certain adults with heart failure (condition in which the heart is unable to pump enough blood to the other parts of the body) to decrease the risk that their condition will worsen and need to be treated in a hospital. It is also used to treat a certain type of heart failure in children 6 mo… Read the full Ivabradine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Boceprevir Tucatinib Voriconazole Ziprasidone Troleandomycin

39 Contraindicated 231 Major 5 Moderate

All (275) Contraindicated (39) Major (231) Moderate (5)

Contraindicated

Ivabradine Bepridil An increased risk of QT interval prolongation Details Ivabradine Boceprevir Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Ceritinib Zykadia Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Cisapride Propulsid® Increased risk of QT interval prolongation Details Ivabradine Clarithromycin Biaxin Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Cobicistat Tybost Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Conivaptan Vaprisol Increased ivabradine exposure Details Ivabradine Darunavir Increased ivabradine exposure Details Ivabradine Dronedarone Multaq Increased risk of QT interval prolongation Details Ivabradine Ensitrelvir Increased ivabradine exposure and an increased risk of ivabradine-related adverse events Details Ivabradine Fluconazole Diflucan Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details Ivabradine Idelalisib Zydelig Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Indinavir Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Itraconazole Sporanox Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Ketoconazole Extina Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Lefamulin Xenleta Increased sensitive CYP3A4 substrates exposure and an increased risk of QT interval prolongation Details Ivabradine Lonafarnib Zokinvy Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Mesoridazine An increased risk of QT interval prolongation Details Ivabradine Mifepristone Korlym Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Nefazodone Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Nelfinavir Viracept Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Nirmatrelvir Increased ivabradine exposure and an increased risk of bradycardia or conduction disturbances Details Ivabradine Paritaprevir Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Pimozide An increased risk of QT interval prolongation Details Ivabradine Piperaquine Increased exposure of CYP3A4 substrates and an increased risk of QT interval prolongation Details Ivabradine Posaconazole Noxafil Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Ribociclib Kisqali Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Ritonavir Norvir Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Saquinavir Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Sparfloxacin An increased risk of QT interval prolongation Details Ivabradine Telaprevir Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Telithromycin Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Terfenadine An increased risk of QT interval prolongation Details Ivabradine Thioridazine An increased risk of QT interval prolongation Details Ivabradine Troleandomycin Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Tucatinib Tukysa Increased ivabradine exposure and an increased risk of ivabradine-related adverse effects [like bradycardia and conduction disturb... Details Ivabradine Voriconazole Vfend Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details Ivabradine Ziprasidone Geodon An increased risk of QT interval prolongation Details Ivabradine Ketoconazole Topical Extina® Foam Increased ivabradine exposure, an increased risk of ivabradine-related adverse effects and an increased risk of QT prolongation Details

Major

Ivabradine Amitriptyline Elavil Increased risk of QT prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.