Lansoprazole

Name: Lansoprazole Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

94 interactions 507 cited references

Also sold as: Prevacid Prevacid® Prevacid® 24HR Prevacid® SoluTab®

About Lansoprazole

Lansoprazole is a proton pump inhibitor used to treat acid reflux, heartburn, and stomach ulcers. Read the full Lansoprazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rilpivirine Ziftomenib Belumosudil Octreotide Injection Gefitinib Infigratinib

1 Contraindicated 69 Major 21 Moderate 3 Minor

All (94) Contraindicated (1) Major (69) Moderate (21) Minor (3)

Minor

Lansoprazole Clarithromycin Biaxin Glossitis, stomatitis, or black tongue Details Lansoprazole Ponatinib Iclusig Decreased ponatinib efficacy Details Lansoprazole Sucralfate Carafate Reduced lansoprazole bioavailability Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.