Lansoprazole

94 interactions 507 cited references
Also sold as: Prevacid Prevacid® Prevacid® 24HR Prevacid® SoluTab®
About Lansoprazole

Lansoprazole is a proton pump inhibitor used to treat acid reflux, heartburn, and stomach ulcers. Read the full Lansoprazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Rilpivirine Ziftomenib Belumosudil Octreotide Injection Gefitinib Infigratinib
1 Contraindicated 69 Major 21 Moderate 3 Minor
All (94) Contraindicated (1) Major (69) Moderate (21) Minor (3)

Moderate

Lansoprazole Ampicillin Amcill® Loss of ampicillin efficacy Details Lansoprazole Ampicillin Injection Omnipen-N® Loss of ampicillin efficacy Details Lansoprazole Ceftriaxone Injection Rocephin® Increased risk of ventricular arrhythmias Details Lansoprazole Clopidogrel Plavix Reduced antiplatelet activity Details Lansoprazole Doxycycline Injection Acticlate Reduced doxycycline efficacy Details Lansoprazole Acenocoumarol Elevations in International Normalized Ratio serum values and potentiation of anticoagulation effects Details Lansoprazole Ceftriaxone Increased risk of ventricular arrhythmias Details Lansoprazole Cenobamate Xcopri Increased exposure to CYP2C19 substrates and/or increased risk of adverse effects Details Lansoprazole Dicumarol Elevations in International Normalized Ratio serum values and potentiation of anticoagulation effects Details Lansoprazole Doxycycline Acticlate Reduced doxycycline efficacy Details Lansoprazole Iron Reduced iron bioavailability Details Lansoprazole Itraconazole Sporanox Reduced itraconazole exposure Details Lansoprazole Levothyroxine Ermeza Reduced efficacy of levothyroxine and an increased risk of hypothyroidism Details Lansoprazole Mavacamten Camzyos Reduced CYP2C19 substrate exposure and reduced efficacy of CYP2C19 substrate Details Lansoprazole Phenprocoumon Elevations in International Normalized Ratio serum values and potentiation of anticoagulation effects Details Lansoprazole Piperaquine Increased exposure of CYP2C19 substrates Details Lansoprazole Rifampin Rifadin Decreased lansoprazole exposure Details Lansoprazole Risedronate Actonel Increased risedronate bioavailability Details Lansoprazole St John's Wort Decreased lansoprazole exposure Details Lansoprazole Sultamicillin Loss of ampicillin efficacy Details Lansoprazole Warfarin Coumadin Elevations in International Normalized Ratio serum values and potentiation of anticoagulation effects Details

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