Levoketoconazole

185 interactions 11 explained in plain English

Also sold as: Recorlev Recorlev®

About Levoketoconazole

Levoketoconazole is used to treat high levels of cortisol (a hormone produced by your adrenal glands) in patients with Cushing's syndrome (a condition in which the body produces too much cortisol) and who have failed surgery or cannot have surgery to treat this condition. Levoketoconazole is in a class of medications c… Read the full Levoketoconazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metronidazole Injection Mefloquine Hydroxychloroquine Oxaliplatin Injection Clindamycin Topical Chloroquine

103 Contraindicated 82 Major

All (185) Contraindicated (103) Major (82)

Contraindicated

Levoketoconazole Mefloquine Lariam® An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Metronidazole Flagyl An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Metronidazole Injection Flagyl An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Metronidazole Topical MetroCream® An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Midazolam Nasal Spray Nayzilam Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Midazolam Injection Nayzilam Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Moxifloxacin Avelox An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Moxifloxacin Injection Avelox An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation, an increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Naloxegol Movantik Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Neratinib Nerlynx Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Nicardipine Cardene An increased risk of QT interval prolongation and torsades de pointes, an increased niCARdipine exposure, and an increased risk of... Details Levoketoconazole Nisoldipine Sular Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Octreotide Bynfezia An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Octreotide Injection Bynfezia An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Ofloxacin Floxin® An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Olaparib Lynparza Increased CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related adverse reaction Details Levoketoconazole Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Levoketoconazole Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details

Major

Levoketoconazole Abacavir Ziagen Explained Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Omeprazole Gastrobim Explained Reduced levoketoconazole exposure Details Levoketoconazole Acarbose Prandase® Explained Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Acetazolamide Diamox® Sequels® Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Adalimumab Injection Abrilada Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Albendazole Albendamax Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Allopurinol Aloprim Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Allopurinol Injection Aloprim Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Ambrisentan Letairis Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Atovaquone Mepron Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Azacitidine Onureg Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Bicalutamide Casodex Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Atorvastatin Atorvaliq Increased atorvastatin exposure and an increased risk of atorvastatin-related adverse effects Details Levoketoconazole Azacitidine Injection Onureg Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Bexarotene Targretin Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Bexarotene Topical Targretin Increased risk of serious hepatotoxicity and drug-induced liver injury Details Levoketoconazole Bortezomib Boruzu Increased risk of serious hepatotoxicity and drug-induced liver injury Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.