Levonorgestrel Intrauterine System

211 interactions 370 cited references
Also sold as: Kyleena Kyleena® Liletta Liletta® Mirena Mirena® Skyla Skyla®
About Levonorgestrel Intrauterine System

Levonorgestrel intrauterine system (Liletta, Kyleena, Mirena, Skyla) is used to prevent pregnancy. The Mirena brand intrauterine system is also used to treat heavy menstrual bleeding in women who want to use an intrauterine system to prevent pregnancy. Levonorgestrel is in a class of medications called hormonal contrac… Read the full Levonorgestrel Intrauterine System drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Ritonavir Paritaprevir Ombitasvir Fezolinetant Dasabuvir
6 Contraindicated 170 Major 34 Moderate 1 Minor
All (211) Contraindicated (6) Major (170) Moderate (34) Minor (1)

Major

Levonorgestrel Intrauterine System Penicillin G Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Penicillin G Procaine Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Penicillin V Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Pentobarbital Fatal-Plus Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Pexidartinib Turalio Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Phenobarbital Fidoquel Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Phenylbutazone Equi-Phar Reduced contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleeding and/or... Details Levonorgestrel Intrauterine System Phenytoin Dilantin Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Pimozide Increased pimozide exposure and an increased risk of pimozide-related adverse reactions Details Levonorgestrel Intrauterine System Piperacillin Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Pitolisant Wakix Reduced efficacy of hormonal contraceptives Details Levonorgestrel Intrauterine System Pivampicillin Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Prednisolone Flo-Pred® Increased prednisoLONE exposure and an increased risk of corticosteroid side effects (neuropsychiatric reactions, fluid and electr... Details Levonorgestrel Intrauterine System Prednisone Deltasone Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Primidone Mysoline Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Red Clover Altered contraceptive effectiveness or increased side effects Details Levonorgestrel Intrauterine System Repotrectinib Augtyro Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Rifabutin Mycobutin Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Rifampin Rifadin Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Rifapentine Priftin Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Roflumilast Daliresp Increased roflumilast exposure and an increased risk of roflumilast-related adverse events Details Levonorgestrel Intrauterine System Rolitetracycline Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Rufinamide Banzel Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Saquinavir Altered (increased and reduced) levonorgestrel exposure Details Levonorgestrel Intrauterine System Sarecycline Seysara Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Secobarbital Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptive and an increased risk of breakthrough bleeding... Details Levonorgestrel Intrauterine System Sotagliflozin Inpefa Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Sotorasib Lumakras Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System St John's Wort Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Sugammadex Decreased contraceptive serum concentration and efficacy Details Levonorgestrel Intrauterine System Sultamicillin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Sunvozertinib Zegfrovy Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Levonorgestrel Intrauterine System Tazemetostat Tazverik Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Levonorgestrel Intrauterine System Telaprevir Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Telotristat Ethyl Xermelo Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Temocillin Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding and/or contrace... Details Levonorgestrel Intrauterine System Tetracycline Achromycin V® Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Theophylline Accurbron® Increased theophylline exposure and theophylline toxicity (nausea, vomiting, palpitations, seizures) Details Levonorgestrel Intrauterine System Thiopental Reduced levonorgestrel exposure, reduced efficacy of levonorgestrel and an increased risk of breakthrough bleeding or contraceptiv... Details Levonorgestrel Intrauterine System Thioridazine Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details

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