Levonorgestrel Intrauterine System

211 interactions 370 cited references

Also sold as: Kyleena Kyleena® Liletta Liletta® Mirena Mirena® Skyla Skyla®

About Levonorgestrel Intrauterine System

Levonorgestrel intrauterine system (Liletta, Kyleena, Mirena, Skyla) is used to prevent pregnancy. The Mirena brand intrauterine system is also used to treat heavy menstrual bleeding in women who want to use an intrauterine system to prevent pregnancy. Levonorgestrel is in a class of medications called hormonal contrac… Read the full Levonorgestrel Intrauterine System drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tranexamic Acid Ritonavir Paritaprevir Ombitasvir Fezolinetant Dasabuvir

6 Contraindicated 170 Major 34 Moderate 1 Minor

All (211) Contraindicated (6) Major (170) Moderate (34) Minor (1)

Major

Levonorgestrel Intrauterine System Ticarcillin Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Tigecycline Tygacil Decreased contraceptive effectiveness Details Levonorgestrel Intrauterine System Tipranavir Aptivus Altered (increased and reduced) levonorgestrel exposure Details Levonorgestrel Intrauterine System Tirzepatide Mounjaro Reduced absorption of oral contraceptives Details Levonorgestrel Intrauterine System Tizanidine Increased tiZANidine exposure and an increased risk of tiZANidine-related hypotension, bradycardia or increased drowsiness Details Levonorgestrel Intrauterine System Tocilizumab Actemra Reduced oral contraceptives exposure and reduced efficacy of oral contraceptives Details Levonorgestrel Intrauterine System Topiramate Eprontia Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Tovorafenib Ojemda Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Levonorgestrel Intrauterine System Tramadol ConZip Increased traMADol exposure and an increased risk of seizures, serotonin syndrome and opioid toxicity Details Levonorgestrel Intrauterine System Troleandomycin Increased contraceptive exposure and an increased risk of intrahepatic cholestasis Details Levonorgestrel Intrauterine System Ulipristal Ella Reduced efficacy of ulipristal or progestin-based hormonal contraceptives Details Levonorgestrel Intrauterine System Vemurafenib Zelboraf Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Levonorgestrel Intrauterine System Vorasidenib Voranigo Increased vorasidenib exposure, an increased risk of vorasidenib-related adverse reactions, reduced hormonal contraceptive exposur... Details Levonorgestrel Intrauterine System Voriconazole Vfend Increased voriconazole exposure, increased ethinyl estradiol and norethindrone exposure Details Levonorgestrel Intrauterine System Warfarin Coumadin Altered warfarin exposure, reduced or increased anticoagulant effectiveness and altered INR Details Levonorgestrel Intrauterine System Zanubrutinib Brukinsa Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details

Moderate

Levonorgestrel Intrauterine System Acitretin Soriatane® Loss of contraceptive effectiveness Details Levonorgestrel Intrauterine System Amiodarone Nexterone Increased hormonal contraceptive exposure Details Levonorgestrel Intrauterine System Amitriptyline Elavil Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Intrauterine System Artemether Reduced hormonal contraceptive exposure and an increased artemether/lumefantrine exposure Details Levonorgestrel Intrauterine System Atazanavir Reyataz An increase in exposure to the combination contraceptive Details Levonorgestrel Intrauterine System Clopidogrel Plavix Reduced clopidogrel active metabolite exposure and reduced platelet inhibition Details Levonorgestrel Intrauterine System Desipramine Norpramin Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Intrauterine System Diazepam Diastat Diazepam toxicity (CNS depression, hypotension) Details Levonorgestrel Intrauterine System Dicumarol Decreased anticoagulant effectiveness Details Levonorgestrel Intrauterine System Dofetilide Tikosyn Increased dofetilide exposure Details Levonorgestrel Intrauterine System Dothiepin Attenuation of antidepressant effectiveness; tricyclic toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Intrauterine System Doxepin Prudoxin Attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Intrauterine System Imipramine Possible attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Intrauterine System Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Levonorgestrel Intrauterine System Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Levonorgestrel Intrauterine System Lamotrigine Lamictal Reduced lamoTRIgine exposure and an increased risk of seizures Details Levonorgestrel Intrauterine System Leflunomide Arava Increased levonorgestrel exposure Details Levonorgestrel Intrauterine System Levothyroxine Ermeza Reduced thyroid hormone replacement exposure Details Levonorgestrel Intrauterine System Licorice Increased risk of fluid retention and elevated blood pressure Details Levonorgestrel Intrauterine System Liothyronine Cytomel Reduced thyroid hormone replacement exposure Details Levonorgestrel Intrauterine System Lofepramine Attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details Levonorgestrel Intrauterine System Lorazepam Ativan Decreased lorazepam effectiveness Details Levonorgestrel Intrauterine System Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Levonorgestrel Intrauterine System Nortriptyline Attenuation of antidepressant effectiveness; tricyclic antidepressant toxicity (drowsiness, hypotension, akathisia) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.