Linagliptin and Glyburide: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Linagliptin
Glyburide
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of hypoglycemia
Interaction Deep Dive
Concomitant use of linagliptin and an insulin secretagogue (eg, sulfonylurea) may result in hypoglycemia; lower doses of the insulin secretagogue may be required to reduce the risk of hypoglycemia21. In a clinical trial there was a higher rate of hypoglycemia with linagliptin in combination with an insulin secretagogue compared with placebo 2.
Why it happens (mechanism)
Additive hypoglycemia
Literature reports
1 report — tap to read
a) There was a higher rate of hypoglycemia with linagliptin in combination with an insulin secretagogue compared with placebo in a clinical trial 2.
Common questions
Can I take Linagliptin and Glyburide together?
An increased risk of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Linagliptin and Glyburide interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Linagliptin or Glyburide need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (2)
- Product Information: TRADJENTA(R) oral tablets, linagliptin oral tablets. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2020. DailyMed
- Product Information: GLYXAMBI(R) oral tablets, empagliflozin linagliptin oral tablets. Boehringer Ingelheim Pharmaceuticals Inc (per FDA), Ridgefield, CT, 2021. DailyMed
Keep reading about Linagliptin
Keep reading about Glyburide
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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