Lithium
71 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Metronidazole Injection
Diclofenac Topical (Actinic Keratosis)
Dolasetron
Ibuprofen
Meloxicam
Mefenamic Acid
Major
Lithium Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Lithium Amitriptyline Elavil Explained Increased risk of serotonin syndrome Details Lithium Sertraline Explained An increased risk of serotonin syndrome Details Lithium Lisinopril Prinivil Explained Increased risk of lithium toxicity Details Lithium Buprenorphine Belbuca Explained Increased risk of serotonin syndrome Details Lithium Acetazolamide Diamox® Sequels® Decreased lithium effectiveness or increased lithium concentrations Details Lithium Aspirin Acuprin® Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Aspirin Rectal Aspirin Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Benazepril Lotensin Increased risk of lithium toxicity Details Lithium Azilsartan Edarbi Increased risk of lithium toxicity Details Lithium Bromfenac Ophthalmic Bromday® Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Lithium Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Lithium Canagliflozin Invokana Reduced lithium exposure Details Lithium Candesartan Atacand Increased risk of lithium toxicity Details Lithium Captopril Capoten® Increased risk of lithium toxicity Details Lithium Dapagliflozin Farxiga Reduced lithium exposure Details Lithium Diclofenac Ophthalmic Voltaren® Eye Drops Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Diclofenac Topical (Actinic Keratosis) Pennsaid Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Diclofenac Topical (Arthritis Pain) Pennsaid® Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Diclofenac Transdermal Patch Flector Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Dolasetron Anzemet Increased risk of serotonin syndrome Details Lithium Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Lithium Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Reduced lithium exposure Details Lithium Enalapril Epaned Increased risk of lithium toxicity Details Lithium Eprosartan Teveten® Increased risk of lithium toxicity Details Lithium Ertugliflozin Steglatro Reduced lithium exposure Details Lithium Etodolac Lodine Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Fenoprofen Fenopron Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Lithium Flurbiprofen Ansaid Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Flurbiprofen Ophthalmic Ocufen Increased lithium exposure and an increased risk of lithium toxicity Details Lithium Fosinopril Monopril® Increased risk of lithium toxicity Details Lithium Furosemide Injection Disal An increased risk of lithium toxicity Details Lithium Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Lithium Granisetron Injection Granisol Increased risk of serotonin syndrome Details Lithium Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Lithium Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Lithium Hydroxychloroquine Plaquenil An increased risk of seizures Details Lithium Ibuprofen Addaprin Increased lithium exposure and an increased risk of lithium toxicity DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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