Loratadine

Name: Loratadine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

29 interactions 437 cited references

Also sold as: Agistam® Alavert Alavert® Claritin Claritin® Clear-Atadine® Cleartime Indoor & Outdoor Allergies Dimetapp® ND Loradamed Tavist Non-Sedating Tavist® Non-Sedating Wal-itin Wal-itin® Wal-vert

About Loratadine

An antihistamine used to relieve allergy symptoms like sneezing, runny nose, itchy eyes, and itching from hives. Read the full Loratadine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Mavorixafor Letermovir Injection Amiodarone Apalutamide Avacopan

2 Contraindicated 22 Major 4 Moderate 1 Minor

All (29) Contraindicated (2) Major (22) Moderate (4) Minor (1)

Moderate

Loratadine Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Loratadine Kratom Increased CYP3A substrate exposure Details Loratadine Mavacamten Camzyos Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Loratadine Rilzabrutinib Wayrilz Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.