Loteprednol Ophthalmic

29 interactions 90 cited references
Also sold as: Alrex Alrex® Eysuvis Eysuvis® Inveltys Inveltys® Lotemax Lotemax® Lotemax® SM Zylet® (as a combination product containing Loteprednol, Tobramycin)
About Loteprednol Ophthalmic

Ophthalmic loteprednol products are used to treat different eye conditions: Loteprednol (Inveltys, Lotemax, Lotemax SM) is used to treat swelling and pain after cataract surgery (procedure to treat clouding of the lens in the eye). Loteprednol (Alrex) is used to reduce eye redness, itching, and swelling caused by seaso… Read the full Loteprednol Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Mifepristone Aspirin Bemiparin Carbamazepine Cosyntropin
2 Contraindicated 18 Major 9 Moderate
All (29) Contraindicated (2) Major (18) Moderate (9)

Contraindicated

Loteprednol Ophthalmic Desmopressin DDAVP Increased risk of severe hyponatremia Details Loteprednol Ophthalmic Mifepristone Korlym An increased risk of autoimmune disorders and an increased risk of acute adrenal insufficiency, that may lead to exacerbation or d... Details

Major

Loteprednol Ophthalmic Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Loteprednol Ophthalmic Bemiparin Increased risk of bleeding Details Loteprednol Ophthalmic Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Loteprednol Ophthalmic Cosyntropin False elevations of plasma cortisol levels Details Loteprednol Ophthalmic Ethinyl Estradiol Increased corticosteroid exposure Details Loteprednol Ophthalmic Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Loteprednol Ophthalmic Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Loteprednol Ophthalmic Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Loteprednol Ophthalmic Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Loteprednol Ophthalmic Lutetium Lu 177 Dotatate Decreased lutetium Lu 177 dotatate efficacy Details Loteprednol Ophthalmic Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Loteprednol Ophthalmic Nadroparin Increased risk of bleeding Details Loteprednol Ophthalmic Phenytoin Dilantin Reduced corticosteroid exposure Details Loteprednol Ophthalmic Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Loteprednol Ophthalmic Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, reduced glucocorticoids exposure and reduced efficacy of gluco... Details Loteprednol Ophthalmic Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Loteprednol Ophthalmic Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Loteprednol Ophthalmic Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

Moderate

Loteprednol Ophthalmic Auranofin Ridaura Increased risk of auranofin-related adverse effects Details Loteprednol Ophthalmic Gallium Ga 68 Dotatate Increased risk of false negative imaging Details Loteprednol Ophthalmic Indapamide An increased risk of hypokalemia Details Loteprednol Ophthalmic Insulin Afrezza Reduced blood glucose lowering effect of insulin Details Loteprednol Ophthalmic Insulin Lispro, Recombinant Admelog May decrease blood glucose lowering effect of insulin lispro Details Loteprednol Ophthalmic Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Loteprednol Ophthalmic Olodaterol Striverdi An increased risk of hypokalemia Details Loteprednol Ophthalmic Rotavirus Vaccine, Live An inadequate immunological response to the vaccine Details Loteprednol Ophthalmic Testosterone Androderm Increased risk of edema Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.