Loxoprofen

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Loxoprofen Fondaparinux Injection Arixtra An increased risk of bleeding Details Loxoprofen Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Loxoprofen Heparin An increased risk of bleeding Details Loxoprofen Heparin Injection Lipo-Hepin® An increased risk of bleeding Details Loxoprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Loxoprofen Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Loxoprofen Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Loxoprofen Iloprost Aurlumyn An increased risk of bleeding Details Loxoprofen Ketoprofen Actron® Increased risk of bleeding Details Loxoprofen Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Loxoprofen Meclofenamate Meclodium® Increased risk of bleeding Details Loxoprofen Mefenamic Acid Ponstel® Increased risk of bleeding Details Loxoprofen Meloxicam Alloxate Increased risk of bleeding Details Loxoprofen Meloxicam Injection Alloxate Increased risk of bleeding Details Loxoprofen Melphalan Alkeran An increased risk of bleeding Details Loxoprofen Melphalan Injection Alkeran An increased risk of bleeding Details Loxoprofen Mesalamine Apriso Increased risk of bleeding Details Loxoprofen Mesalamine Rectal Canasa Increased risk of bleeding Details Loxoprofen Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Loxoprofen Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Loxoprofen Nabumetone Relafen Increased risk of bleeding Details Loxoprofen Naproxen Aleve Increased risk of bleeding Details Loxoprofen Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Moderate

Loxoprofen Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Atenolol Tenormin Explained Reduced antihypertensive effect Details Loxoprofen Acebutolol Sectral® Reduced antihypertensive effect Details Loxoprofen Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Betaxolol Betoptic S Reduced antihypertensive effect Details Loxoprofen Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Loxoprofen Bisoprolol Zebeta® Reduced antihypertensive effect Details Loxoprofen Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Loxoprofen Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Esmolol Brevibloc Reduced antihypertensive effect Details Loxoprofen Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Loxoprofen Labetalol Normodyne® Reduced antihypertensive effect Details Loxoprofen Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.