Lumateperone and Isavuconazonium: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Isavuconazonium
Lumateperone
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction
Interaction Deep Dive
Avoid concomitant use of lumateperone (a CYP3A4 substrate) and moderate CYP3A4 inhibitors that also are CYP3A4 inducers may alter (reduced/increase) lumateperone exposure and may increase the risk of adverse reactions. If coadministered, reduce the lumateperone dosage to 21 mg once daily1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of lumateperone; inhibition of CYP3A4-mediated metabolism of lumateperone
Common questions
Can I take Lumateperone and Isavuconazonium together?
Altered (reduced/increased) lumateperone exposure and an increased risk of lumateperone-related adverse reaction Always confirm with your pharmacist or prescriber before making any change.
How serious is the Lumateperone and Isavuconazonium interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Lumateperone or Isavuconazonium need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: CAPLYTA® oral capsules, lumateperone oral capsules. Intra-Cellular Therapies Inc (per manufacturer), Bedminster, NJ, 2025. DailyMed
Keep reading about Isavuconazonium
Keep reading about Lumateperone
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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