Mate and Linezolid Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Linezolid Injection
Mate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Acute headache and increase in blood pressure
Interaction Deep Dive
The primary ingredient of mate is caffeine. Preliminary data suggests that MAOIs may inhibit the metabolism of caffeine, predisposing the patient to signs and symptoms of caffeine excess such as increased blood pressure and headache. A single case report has described such a reaction when phenelzine and caffeine were combined1.
Why it happens (mechanism)
Inhibition of caffeine metabolism
Literature reports
1 report — tap to read
a) A 33-year-old woman stabilized on phenelzine for 4 months experienced a severe headache after drinking 12 fluid ounces of a cola beverage. Her blood pressure increased from 140/85 mmHg to 150/95 mmHg after ingesting the cola beverage. Initially, the headache was assumed to be idiopathic in nature but recurred when the patient again drank 12 fluid ounces of a cola beverage. The author concluded that since a 12 fluid ounce bottle of a cola drink contains 35 milligrams (mg) to 55 mg of caffeine, patients taking MAOIs should exercise extreme caution in combining MAOIs and caffeine 1.
Common questions
Can I take Mate and Linezolid Injection together?
Acute headache and increase in blood pressure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mate and Linezolid Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Mate or Linezolid Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Pakes GE: Phenelzine-cola headache. Am J Hosp Pharm 1979; 36:736. DOI
Keep reading about Linezolid Injection
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