Drug Interaction Report

Mepenzolate and Digoxin: Interaction Details

Name: Mepenzolate and Digoxin Interaction
Creator: Dr. Brian Staiger, PharmD, BCPS

A pharmacist-reviewed analysis of the Mepenzolate and Digoxin interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Mepenzolate

No brand names on record

Digoxin

Cardoxin® Digitek Digitek® Digox Lanoxicaps® Lanoxin Lanoxin®

Medically reviewed by

Dr. Brian Staiger, PharmD, BCPS

Updated Aug 8, 2026

Editorial policy · Data sources

Interaction severity

Moderate

Can be significant — usually manageable with monitoring.

Minor

Moderate

Major

Contraindicated

How we grade severity & evidence

Severity levels

Contraindicated: These should generally not be used together.
Major: Potentially serious — often needs a change or close monitoring.
Moderate: Can be significant — usually manageable with monitoring.
Minor: Usually limited clinical impact.

Evidence grades

Established: Well documented — supported by controlled studies or strong clinical data.
Probable: Good supporting evidence, though not definitively proven.
Suspected: Some evidence suggests this interaction, but it is not well established.
Possible: Limited or conflicting evidence; the interaction may occur.
Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 12 documented Mepenzolate interactions, 1 is rated moderate — including this one.

Onset

unspecified

Evidence

theoretical

Severity

Moderate

What happens

Increased digoxin exposure

Interaction Deep Dive

Use caution if digoxin and mepenzolate are coadministered as this may result in increased digoxin exposure due to altered gastrointestinal absorption, especially with slow dissolving digoxin formulations¹. Monitor digoxin serum concentrations and adjust the dose if necessary. Additionally, monitor for side effects and signs and symptoms of digoxin toxicity.

Why it happens (mechanism)

Altered absorption of digoxin

Common questions

Can I take Mepenzolate and Digoxin together?

Increased digoxin exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Mepenzolate and Digoxin interaction?

It is rated moderate. Can be significant — usually manageable with monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

Does my dose of Mepenzolate or Digoxin need adjusting while I take them together?
What symptoms should prompt me to call you or my prescriber right away?
Does the timing of my doses matter for this combination?
Is there anything you'd monitor while I'm on both?

References (1)

Product Information: CANTIL(R) oral tablets, mepenzolate bromide oral tablets. Sanofi-Aventis U.S. LLC (per DailyMed), Bridgewater, NJ, 2006.

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Mepenzolate

Keep reading about Mepenzolate

All Mepenzolate interactions (12)

Also serious with: Hydromorphone Rectal Glycopyrronium Topical Hydromorphone Injection Glucagon Nasal Powder

Digoxin

Keep reading about Digoxin

All Digoxin interactions (453) Digoxin drug information

Also serious with: Levoketoconazole Meclofenamate Mavorixafor Parathyroid Hormone Injection

Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Digoxin + Activated Charcoal Aloe Blue Flag Danshen European Buckthorn Foxglove Indian Snakeroot Lily-of-the-valley + 105 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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A message from HelloPharmacist

About our interaction database: depth, not breadth

HelloPharmacist doesn't license one of the big commercial interaction databases, so what you'll find here is not a complete list of every known drug interaction. Instead, each entry is researched, analyzed, and written up individually — documented from the published literature, reviewed by a pharmacist, and cited so you can check every source yourself.

If a combination isn't listed here, it means we haven't documented it yet — never that it's safe. For screening a full medication list, we recommend pairing this site with a comprehensive tool like the Drugs.com Interaction Checker and, most importantly, a review by your own pharmacist. For a deep, plain-English, fully sourced explanation of a specific documented interaction — that's exactly what we built this for.

This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.